Bill Murray, Dan Aykroyd and Harold Ramis take up their proton packs once more to battle the forces of evil in Manhattan! After waging a war on slime that cost New York City millions, the Ghostbusters find themselves out of business until an ancient tyrant, preparing a return to the Earthly domain through his portrait at the Manhattan Museum of Modern Art, sets his sights on Dana Barrett's baby as the new home for his wicked soul! With the help of the Museum's possessed curator, he plans to turn New York into a really scary place to live!