Cast / Details
| Rick Moranis | Wayne Szalinski |
| Ron Canada | Marshall Brooks |
| Robert Jaffe | Motorcycle Officer |
| Ron Lawrence | Motorcycle Officer |
| John Hora | Helicopter Observer |
| Julia Sweeney | Nosey Neighbor |
| Marcia Strassman | Diane Szalinski |
| Amy O'Neill | Amy Szalinski |
| Robert Oliveri | Nick Szalinski |
| Leslie Neale | Constance Winters |
| Lloyd Bridges | Clifford Sterling |
| Keri Russell | Mandy Park |
| Alex Daniels | Uncle Yanosh |
| Suzanne Kent | Las Vegas Couple |
| Bill Moseley | Federal Marshal |
| Kenneth Tobey | Smitty |
| Gregory Sierra | Terence Wheeler |
| Michael Milhoan | Captain Ed Myerson |
| Daniel Shalikar | Adam Szalinski |
| Joshua Shalikar | Adam Szalinski |
| Linda Carlson | Nosey Neighbor |
| Lisa Mende | Lab Technician |
| John Paragon | Lab Technician |
| Ed Feldman | Las Vegas Couple |
| John Shea | Dr. Charles Hendrickson |