Meg Altman (Jodie Foster) and her daughter Sarah (Kristen Stewart) play a deadly game of cat and mouse with three intruders - Burnham (Forest Whitaker), Raoul (Dwight Yoakam) and Junior (Jared Leto) - during a brutal home invasion. But the PANIC ROOM into which they escape is the very place that holds what the intruders are desperately seeking.