Questionably diagnosed with Borderline Personality Disorder, Susanna (Winona Ryder) rebels against head nurse (Whoopi Goldberg) and top psychiatrist (Vanessa Redgrave), choosing instead to befriend the resident "loonies" -- a group of troubled women including the seductively charismatic sociopath Lisa (Angelina Jolie). But Susanna quickly learns that if she wants her freedom, she'll have to face the person who terrifies her most of all: herself.