In Baltimore, a group of unrelated people deal with love and the challenges of reading or misreading human behavior. Jennifer Connelly plays a woman stuck in a tired marriage with a cheating husband (Bradley Cooper). Another man pines after a woman who is having an affair with a married man.

A young woman (Ginnifer Goodwin) is obsessed with a man and tries to set up accidental meetings with him only to run across his friend (Justin Long), who takes her on as a "My Fair Lady" experiment.

Drew Barrymore plays a woman perpetually confused by dating, now more than ever in a culture that is more obsessed with technology than actual human contact. Based on the best-selling book by Greg Behrendt and Liz Tuccillo.